Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development

Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to known human carcinogens including dioxins can lead promotion breast cancer. While repressor protein AhR (AhRR) blocks canonical pathway, function AhRR in development cancer is not well-known. In current study we examined impact suppressing activity using its dedicated AhRR. a putative tumor suppressor and silenced several types, breast, where loss correlates with shorter patient survival. Using transgenic mouse, demonstrate that overexpression opposes AhR-driven inflammation-induced growth mammary tumors two different murine models These include syngeneic model E0771 cells as well Polyoma Middle T antigen (PyMT) model. Further or knockout enhanced apoptosis induced by chemotherapeutics inhibited mouse cells. This provides first vivo evidence suppresses suggests strategies which functional restoration expression may have therapeutic benefit.